This repository includes code for the following paper:
Brain regions within a posterior medial network (PMN) are characterized by sensitivity to episodic tasks, and they also demonstrate strong functional connectivity as part of the default network. Despite its cohesive structure, delineating the intranetwork organization and functional diversity of the PMN is crucial for understanding its contributions to multidimensional event cognition. Here, we probed functional connectivity of the PMN during movie watching to identify its pattern of connections and subnetwork functions in a split-sample replication of 136 participants. Consistent with prior findings of default network fractionation, we identified distinct PMN subsystems: a Ventral PM subsystem (retrosplenial cortex, parahippocampal cortex, posterior angular gyrus) and a Dorsal PM subsystem (medial prefrontal cortex, hippocampus, precuneus, posterior cingulate cortex, anterior angular gyrus). Ventral and Dorsal PM subsystems were differentiated by functional connectivity with parahippocampal cortex and precuneus and integrated by retrosplenial cortex and posterior cingulate cortex, respectively. Finally, the distinction between PMN subsystems is functionally relevant: whereas both Dorsal and Ventral PM connectivity tracked the movie content, only Ventral PM connections increased in strength at event transitions and appeared sensitive to episodic memory. Overall, these findings reveal PMN functional pathways and the distinct functional roles of intranetwork subsystems during event cognition.
FMRI data was preprocessed with fMRIPrep and denoised with the CONN toolbox using fMRIPrep-generated confounds. Connectivity analyses were run using Matlab (functions from cosmomvpa and SPM) and R Studio.
CamCan-PM-network_[Discovery/Replication].Rmd— the Group 1 (Discovery) report can be viewed here and the Group 2 (Replication) report can be viewed here.
CamCan-PM-network_Memory.Rmd— the results report can be viewed here.
All code is licensed under the MIT license.
Please direct any comments or questions to Rose Cooper, rose.cooper at bc.edu. Please feel free to use any of these scripts. Unfortunately I cannot provide support for you to adapt them to your own data. Notice a bug? Please tell me!