This repository includes scripts and data for the following paper:
Episodic memories reflect a bound representation of multimodal features that can be reinstated with varying levels of precision. Yet little is known about how brain networks involved in memory, including the hippocampus and posterior-medial (PM) and anterior-temporal (AT) cortical systems, functionally interact to support the quality and the content of recollection. Participants learned color, spatial, and emotion associations of objects, later reconstructing the visual features using a continuous color spectrum and 360° panorama scenes. Behaviorally, dependencies in memory were observed for the gist but not precision of these event associations. Supporting this integration, hippocampus, AT, and PM regions showed increased inter-network connectivity and reduced modularity during retrieval compared to encoding. These network connections, particularly to hippocampus, tracked a multidimensional, continuous measure of objective memory quality. Moreover, distinct patterns of connectivity tracked item color precision and spatial memory precision. These findings demonstrate not only how hippocampal-cortical connections reconfigure during episodic retrieval, but how such dynamic interactions might flexibly support the multidimensional quality of remembered events.
I have also shared a few key analysis scripts in the
analysis folder along with some corresponding
data files and
The general flow of the included analysis scripts is as follows:
Orbit-fMRI-Univariate_Paper.Rmd. This script analyzes first level betas in
Univariate_MemoryQuality_data.csv, reflecting the change in mean ROI activity with increasing memory quality.
conn_batch_firstlevel_background.m. This script requires that all task regressors have already been generated.
Orbit-fMRI-BackgroundConnectivity_Paper.Rmd. This script calls functions in
background_functions_paper.Rto format, analyze, and visualize the connectivity matrices at the group level.
conn_batch_firstlevel_memorygPPI.m. This script requires that all task regressors have already been generated.
Orbit-fMRI-MemorygPPI_Paper.Rmd. This script calls functions in
gPPI_functions_paper.Rto format, analyze, and visualize the network and ROI connectivity matrices at the group level.
Please direct any comments to Rose Cooper, rose.cooper at bc.edu. Please feel free to use any of these scripts. Unfortunately I cannot provide support for you to adapt them to your own data. Notice a bug? Please tell me.